The Importance Of Differential Pressure In Pharma Cleanrooms
- 14, 07, 2021
Differential pressure plays an important role in cleanrooms, especially pharmaceutical cleanrooms. This article will identify the importance of that element in pharmaceutical manufacturing cleanrooms.
The differential pressure refers to the difference in air pressure from one location to another within a system. In pharma factories, the differential pressure usually implies the difference in pressure between production area and surrounding areas.
According to GMP WHO, the widely accepted differential pressure between pharma manufacturing area and the surroundings is 15 Pa. Cleanrooms should be highly pressurized than non-cleanrooms. In drug production area, the differential pressure helps to keep the pollutants out and prevent cross-contamination.
Dust particles are usually generated in granulation process, which can contaminate other products in adjacent areas. Differential pressure prevents dust particles from entering manufacturing cleanrooms.
To minimize the cross-contamination, it is important to maintain the positive pressure in the corridor than drug manufacturing areas. Before entering the corridor, workers have to go through the airlocks.
It is important to carry out the differential pressure validation at the time of HVAC system validation.
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